WebIntroduction: The COVID-19 pandemic had significant impact on clinical care and clinical trial operations, but the impact on decentralized pragmatic trials is unclear. The Diuretic Comparison Project (DCP) is a Point-of Care (POC) pragmatic trial testing whether chlorthalidone is superior to hydrochlorothiazide in preventing major cardiovascular (CV) … WebPragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records addresses the practical aspects and challenges of the design, implementation, …
Pragmatic Randomized Clinical Trials ScienceDirect
WebThere is overlap between the classic randomized clinical trial and the pragmatic clinical trial. Instead of focusing on the definitions and dividing clinical trials into two baskets, it … WebApr 12, 2024 · The National Cancer Institute, part of the National Institutes of Health (NIH), has helped launch a phase 3 randomized clinical trial (NCT05633602) of a two-drug … help desk university of richmond
A Pragmatic Randomized Trial to Evaluate the Effectiveness of …
Pragmatism in clinical trials arose from concerns that many trials did not adequately inform practice because they were optimized to determine efficacy.1 Because such trials were performed with relatively small samples at sites with experienced investigators and highly selected participants, they could be … See more In this article, we do not provide a definitive exposition of the methods used for pragmatic trials. Rather, we explore the contexts in which a pragmatic design is most and least … See more The ongoing High-Sensitivity Troponin in the Evaluation of Patients with Acute Coronary Syndrome (High-STEACS) trial31 is investigating the … See more Schwartz and Lellouch1 proposed a distinction between explanatory trials, which confirm a physiological or clinical hypothesis, and … See more In the CRASH trial, more than 10,000 patients with head injury and impaired consciousness underwent randomization to determine whether … See more WebThis pragmatic, head-to-head, randomized clinical trial of the two clinically recommended approaches to screening for gestational diabetes, 1,9 showed no significant differences in … WebJul 23, 2024 · Pragmatic research is not ‘less than’ research, it is really ‘different than’ efficacy research. It is equally rigorous but broader and has a different purpose: it … la mer moisturizing cream benefits