Oxazaphosphorine
WebTetrahydro-2-(bis(2-chloroethyl)amino)-3-methyl-2H-1,3,2-oxazaphosphorine 2-oxide C8H17Cl2N2O2P CID 211031 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. WebIf the oxazaphosphorine dose is adjusted, the mesna dose should also be modified to maintain the mesna-to-oxazaphosphorine drug ratio. IV Bolus: 20% of the oxazaphosphorine dose at 0 hr, 4 hrs and 8 hrs Oral: 20% IV at 0 hr, 40% p.o …
Oxazaphosphorine
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WebMay 1, 2010 · The oxazaphosphorines (cyclophosphamide, ifosfamide and trofosfamide) are widely used in clinical practice for their antitumor and immunomodulatory activities. … WebIntratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy. In: Walden, P., Trefzer, U., Sterry, W., …
WebOxazaphosphorine metabolism is affected by a number of factors associated with the drugs (e.g., dosage, route of administration, chirality, and drug combination) and patients (e.g., age, gender, renal and hepatic function). Several drug transporters, such as breast cancer resistance protein (BCRP), multidrug resistance associated proteins (MRP1 ... WebCyclophosphamide monohydrate, 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan. Empirical Formula (Hill Notation): C 7 H 15 Cl 2 N 2 O 2 P · H 2 O. CAS Number: 6055-19-2. Molecular Weight: 279.10. Beilstein: 4678992. MDL number: MFCD00149395. PubChem Substance ID: 329775031. NACRES: NA.24. …
Webother oxazaphosphorine cytostatics like Ifosfamide (IF). The enzymatic cleavage of ALDO to form PAM and HPA is important for another reason that makes CP exceptional as an alkylating cytostatic. HPA - which becomes acrolein by elimination of water - is a pro-apoptotic aldehyde that promotes apoptosis by inhibiting the anti- Web2-Phenyltetrahydro-2H-1,3,2-oxazaphosphorine. Molecular Weight: 181.17. Dates: Modify . 2024-04-01. Create . 2007-02-08. Contents. 1 Structures Expand this section. 2 Names and Identifiers Expand this section. 3 Chemical and Physical Properties Expand this section. 4 Related Records Expand this section. 5 Information Sources. 1 Structures. Help.
WebBackground: Oxazaphosphorines (cyclophosphamide (CPA), ifosfamide (IFO)) are major alkylating agents of polychemotherapy protocols but limiting their toxicity and increasing their efficacy could be of major interest. Oxazaphosphorines are prodrugs that require an activation by cytochrome P450 (CYP).
WebCyclophosphamide ( CP ), also known as cytophosphane among other names, [3] is a medication used as chemotherapy and to suppress the immune system. [4] As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. [4] scorched pot cleanerWebOxazaphosphorine metabolism and transport have a major impact on pharmacokinetic variability, pharmacokinetic-pharmacodynamic relationship, toxicity, resistance, and drug … precut cathedral window quiltWebThe oxazaphosphorines cyclophosphamide, ifosfamide and trofosfamide remain a clinically useful class of anticancer drugs with substantial antitumour activity against a variety of … precut canvas for a teepeeWebThe oxazaphosphorine cyclophosphamide is one of the most widely used drugs in cancer chemotherapy. It is also used as an immunosuppressive at lower doses. As with the other anticancer drugs discussed in previous sessions, it is a prodrug. scorched pot dryer sheetWebOxazaphosphorine C3H4NOP CID 22137869 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and … pre cut ceramic window tintWebJan 30, 2009 · P-Stereogenic oxazaphosphorine compounds of the form 4 have not previously been reported as asymmetric ligands for metal-catalyzed reactions. In an effort to explore the behavior of such oxazaphosphorine ligands, monomeric oxazaphosphorine borane 9 and dimeric oxazaphosphorine boranes 25 and 26 were synthesized as catalyst … pre cut cardstock for invitationsscorched pot remedy